In video games
In
Pokémon Red and
Blue, the player learns of Mewtwo's existence through research notes left in the ruined "Pokémon Mansion" on Cinnabar Island, which describe it as being born from Mew due to the efforts of a solitary scientist,
[19][8] but proved too powerful to control, destroying the laboratory and escaping. The player is later given an opportunity to capture Mewtwo in the Cerulean Cave, which is accessible only after defeating the game's final
bosses, the
Elite Four and
Blue;
[20] in the remake titles
Pokémon FireRed and LeafGreen the prerequisite was expanded, requiring additional exploration and the player having recording information on sixty Pokémon species before access to the cave would be granted.
[21]
Since his debut Mewtwo has appeared in other Nintendo games in major roles. In games such as
Pokémon Stadium and
Pokémon Pinball, Mewtwo appears as a final boss after all competitions have been completed.
[22][23] In
Pokémon Puzzle League, Mewtwo serves not only as the final opponent but also as the one responsible for game's events.
[24] Other games, such as
Super Smash Bros. Melee and the
Pokémon Mystery Dungeon series have featured Mewtwo as an
unlockable player character that must be defeated beforehand,
[25][26] while games such as
Pokémon Snap have featured the character in
cameos, appearing once certain conditions have been met.
[27] For all appearances in which the character has spoken dialogue, Mewtwo is voiced by
Masachika Ichimura with the exception of
Pokémon Puzzle League, which is voiced by
Phillip Bartlett instead.
[1]